Spatial Genome Architecture in Development and Disease
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Subprojects
3D chromatin organisation in direct neuronal reprogramming – reshaping the nucleus to mold new neurons
Regulation of mammalian genome architecture and mobility
Assessing the Function and Dynamics of Spatial Genome Architecture during Embryogenesis
Understanding how changes in spatial chromatin organization cause defective gene expression in acute myeloid leukemia with cohesin mutations.
Single molecule imaging of architectural proteins during zebrafish embryo development
Measuring genome organization during stem cell differentiation with super-resolution microscopy
Nuclear landscape of HIV-1 integration in microglia – unexplored HIV-1 reservoirs
Structuring the genome through phase-separated transcriptional condensates
Determining TADs as conserved regulatory units in vertebrate heart development
Evolution of 3D chromatin architecture: The role of CTCF across taxa
Modification of 3D genome architecture and gene expression at the Fgf8 locus by transposable elements and structural variations
Exploring the contribution of transcription to native chromatin looping and genome conformation
Cell-state specific 3D genome architecture in heterogeneous cell populations of the brain.
Dissecting the role of chromosome genome organization in chromosome fragility and the formation of leukemia driving translocations.
Identification of functional genetic variants affecting allele-specific chromatin conformation using Genome Architecture Mapping
Position effects in the 3D genome as the cause of neurodevelopmental disorders
Functional Characterization and Heterogeneity of the DLBCL and AML 3D Genomes
From fibers to the sea of nuclesomes: Computer simulations of the regulation of the spatial structure of Mbp chromatin domains in the nucleus
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